Neutrophil CD64 by Flow Cytometry Has Excellent Negative Predictive Value for Excluding Sepsis
نویسندگان
چکیده
منابع مشابه
Comparison of the accuracy of neutrophil CD64 and C-reactive protein as a single test for the early detection of neonatal sepsis
PURPOSE Early identification of neonatal sepsis is a global issue because of limitations in diagnostic procedures. The objective of this study was to compare the diagnostic accuracy of neutrophil CD64 and C-reactive protein (CRP) as a single test for the early detection of neonatal sepsis. METHODS A prospective study enrolled newborns with documented sepsis (n=11), clinical sepsis (n=12) and ...
متن کاملNeutrophil CD64 as a diagnostic marker of sepsis in neonates.
BACKGROUND Sepsis in neonates hospitalized in the neonatal intensive care unit is a global problem and is a significant contributor to morbidity and mortality. Neutrophil surface CD64, the high-affinity Fc receptor, is quantitatively up-regulated during infection and sepsis. OBJECTIVE Our goal in this prospective study was to measure the neutrophil CD64 in blood as an adjunct to our previousl...
متن کاملEvaluation of CD64 Expression on Peripheral Blood Neutrophils for Early Detection of Neonatal Sepsis
Background: Neonatal sepsis is a life-threatening disease with an incidence of 1 to 10 per 1000 live births and a mortality rate of 15% to 50%. The clinical signs are non-specific and indistinguishable from those caused by a variety of neonatal noninfectious disorders. Objective: The aim of this study was to determine the importance of CD64 expression (FcgRI), a neutrophil surface marker, in ea...
متن کاملDynamics of human neutrophil aggregation evaluated by flow cytometry.
In order to directly monitor neutrophil aggregation, we have developed a simple particle counting technique using flow cytometry. Flow times were used to determine aggregation from changes in the total number of particles per unit volume (%PA(T)), while fluorescent signals emitted from glutaraldehyde-fixed neutrophils were used to measure changes in the total number of singlet neutrophils (%PA(...
متن کاملFlow Cytometric Determination of Neutrophil CD64 (nCD64) in Children with Community Acquired Pneumonia
Background The expression of CD64 in neutrophils (nCD64) has shown utility in the diagnosis of sepsis. The aim of this study was to evaluate the diagnostic value of neutrophil CD64 in pneumonia as an early marker for infection and correlate its level with the outcome of...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2015
ISSN: 0002-9173,1943-7722
DOI: 10.1093/ajcp/144.suppl2.144